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CAS No.1513857-77-6 | Pemigatinib

Name:Pemigatinib CAS No.1513857-77-6 MF:C24H27F2N5O4 MW:487.5 Purity:98% Package: 1g,5g,10g,50g,250g Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 1513857-77-6 | Pemigatinib

Synonyms:3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one;

INCB-054828;

3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one;

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one,3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-;

IBI-375;

3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one;2H8]-Pemigatinib

Specification:

ITEMS	SPECIFICATION
CAS	1513857-77-6
MF	C24H27F2N5O4
MW	487.5
Boiling point	697.6±55.0 °C
Density	1.44±0.1 g/cm3
Acidity coefficient	11.56±0.40
Solubility	DMSO: 40.0 (maximum concentration mg/mL); 82.05 (maximum concentration mM)
Form	crystalline solid
Storage condition	Store at -20°C

Biological activity:

Pemigatinib (INCB054828, Pemazyre) is an orally active and selective inhibitor of FGFR, with IC50s of 0.4nM, 0.5nM, 1.2nM and 30nM for FGFR1, FGFR2, FGFR3 and FGFR4 respectively. Pemigatinib (INCB054828) has the potential to treat cholangiocarcinoma.

Package and transportation :

Package: 1g,5g,10g,50g,250g